VOLUME 6 (2015)
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NZ-1 and MASL exhibit different OSCC cell binding dynamics. MASL bound to cell membranes (shown) with unexpected efficiency. See Ochoa-Alvarez et al.
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Table of Contents
Editorial
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| Liver polyploidy: Dr Jekyll or Mr Hide |
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https://doi.org/10.18632/oncotarget.3809
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| 8430-8431 |
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| Intracellular HMGB1: defender of client proteins and cell fate |
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https://doi.org/10.18632/oncotarget.3836
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| 8432-8433 |
Reviews
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| The microRNA feedback regulation of p63 in cancer progression |
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https://doi.org/10.18632/oncotarget.3020
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| 8434-8453 |
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| Targeting Hsp90 in urothelial carcinoma |
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https://doi.org/10.18632/oncotarget.3502
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| 8454-8473 |
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| MicroRNAs in apoptosis autophagy and necroptosis |
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https://doi.org/10.18632/oncotarget.3523
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| 8474-8490 |
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| The biology and treatment of oligometastatic cancer |
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https://doi.org/10.18632/oncotarget.3455
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| 8491-8524 |
Priority Research Papers
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| Kinaseindependent role of cyclin D1 in chromosomal instability and mammary tumorigenesis |
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https://doi.org/10.18632/oncotarget.3267
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| 8525-8538 |
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| Pharmacological inhibition of p38 MAPK reduces tumor growth in patientderived xenografts from colon tumors |
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https://doi.org/10.18632/oncotarget.3816
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| 8539-8551 |
Research Papers: Gerotarget (Focus on Aging)
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| A mutation in the NADHdehydrogenase subunit 2 suppresses fibroblast aging |
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https://doi.org/10.18632/oncotarget.3298
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| 8552-8566 |
Research Papers
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| Antiβ2microglobulin monoclonal antibodies overcome bortezomib resistance in multiple myeloma by inhibiting autophagy |
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https://doi.org/10.18632/oncotarget.3251
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| 8567-8578 |
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| Prognostic and predictive values of long noncoding RNA LINC00472 in breast cancer |
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https://doi.org/10.18632/oncotarget.3287
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| 8579-8592 |
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| Crosstalk between Desmoglein 2 and Patched 1 accelerates chemicalinduced skin tumorigenesis |
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https://doi.org/10.18632/oncotarget.3309
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| 8593-8605 |
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| D2hydroxyglutarate is essential for maintaining oncogenic property of mutant IDHcontaining cancer cells but dispensable for cell growth |
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https://doi.org/10.18632/oncotarget.3330
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| 8606-8620 |
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| DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/βcatenin signaling |
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https://doi.org/10.18632/oncotarget.3281
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| 8621-8634 |
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| RIPK3 expression in cervical cancer cells is required for PolyICinduced necroptosis IL1α release and efficient paracrine dendritic cell activation |
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https://doi.org/10.18632/oncotarget.3249
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| 8635-8647 |
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| Basal and therapydriven hypoxiainducible factor1α confers resistance to endocrine therapy in estrogen receptorpositive breast |
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https://doi.org/10.18632/oncotarget.3257
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| 8648-8662 |
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| Enhancement of tumor initiation and expression of KCNMA1 MORF4L2 and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment |
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https://doi.org/10.18632/oncotarget.3536
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| 8663-8675 |
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| A novel role for microRNA1295p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional coactivators YAP and TAZ |
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https://doi.org/10.18632/oncotarget.3254
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| 8676-8686 |
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| The stromal genome heterogeneity between breast and prostate tumors revealed by a comparative transcriptomic analysis |
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https://doi.org/10.18632/oncotarget.3478
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| 8687-8697 |
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| Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERKmediated stabilization of Bcl2 protein by phosphorylation at Serine 87 |
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https://doi.org/10.18632/oncotarget.3537
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| 8698-8708 |
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| Cleaved CD44 intracellular domain supports activation of stemness factors and promotes tumorigenesis of breast cancer |
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https://doi.org/10.18632/oncotarget.3325
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| 8709-8721 |
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| Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma |
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https://doi.org/10.18632/oncotarget.2726
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| 8722-8735 |
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| PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins |
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https://doi.org/10.18632/oncotarget.3538
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| 8736-8749 |
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| Biological rational for sequential targeting of Bruton tyrosine kinase and Bcl2 to overcome CD40induced ABT199 resistance in mantle cell lymphoma |
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https://doi.org/10.18632/oncotarget.3275
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| 8750-8759 |
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| TRPM7 maintains progenitorlike features of neuroblastoma cells: implications for metastasis formation |
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https://doi.org/10.18632/oncotarget.3315
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| 8760-8776 |
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| Overexpression of Rad51C splice variants in colorectal tumors |
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https://doi.org/10.18632/oncotarget.3209
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| 8777-8787 |
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| Targeted therapy of glioblastoma stemlike cells and tumor nonstem cells using cetuximabconjugated ironoxide nanoparticles |
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https://doi.org/10.18632/oncotarget.3554
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| 8788-8806 |
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| Anterior gradient protein 2 expression in high grade head and neck squamous cell carcinoma correlated with cancer stem cell and epithelial mesenchymal transition |
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https://doi.org/10.18632/oncotarget.3556
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| 8807-8821 |
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| The attenuated hepatocellular carcinomaspecific Listeria vaccine LmddMPFG prevents tumor occurrence through immune regulation of dendritic cells |
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https://doi.org/10.18632/oncotarget.3558
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| 8822-8838 |
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| Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxylterminal deletion mutants |
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https://doi.org/10.18632/oncotarget.3559
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| 8839-8850 |
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| The protooncogene cSrc and its downstream signaling pathways are inhibited by the metastasis suppressor NDRG1 |
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https://doi.org/10.18632/oncotarget.3316
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| 8851-8874 |
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| MicroRNA profiling identifies MiR195 suppresses osteosarcoma cell metastasis by targeting CCND1 |
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https://doi.org/10.18632/oncotarget.3560
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| 8875-8889 |
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| Dual effects of collagenase3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry |
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https://doi.org/10.18632/oncotarget.3189
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| 8890-8899 |
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| Macrophages promote benzopyreneinduced tumor transformation of human bronchial epithelial cells by activation of NFκB and STAT3 signaling in a bionic airway chip culture and in animal models |
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https://doi.org/10.18632/oncotarget.3561
|
| 8900-8913 |
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| MiR203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelialmesenchymal transition via SNAI2 |
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https://doi.org/10.18632/oncotarget.3563
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| 8914-8928 |
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| Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization |
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https://doi.org/10.18632/oncotarget.3369
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| 8929-8946 |
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| Split anergized Natural Killer cells halt inflammation by inducing stem cell differentiation resistance to NK cell cytotoxicity and prevention of cytokine and chemokine secretion |
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https://doi.org/10.18632/oncotarget.3250
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| 8947-8959 |
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| Dual targeting of microtubule and topoisomerase II by αcarboline derivative YCH337 for tumor proliferation and growth inhibition |
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https://doi.org/10.18632/oncotarget.3264
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| 8960-8973 |
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| GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth |
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https://doi.org/10.18632/oncotarget.3291
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| 8974-8987 |
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| Novel harmine derivatives for tumor targeted therapy |
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https://doi.org/10.18632/oncotarget.3276
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| 8988-9001 |
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| Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer |
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https://doi.org/10.18632/oncotarget.3282
|
| 9002-9017 |
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| Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes |
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https://doi.org/10.18632/oncotarget.3379
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| 9018-9030 |
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| WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP9 and VEGFC |
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https://doi.org/10.18632/oncotarget.3320
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| 9031-9044 |
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| Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms |
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https://doi.org/10.18632/oncotarget.3515
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| 9045-9060 |
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| IL32α suppresses colorectal cancer development via TNFR1mediated death signaling |
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https://doi.org/10.18632/oncotarget.3197
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| 9061-9072 |
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| Dual inhibition of HDAC and EGFR signaling with CUDC101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer |
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https://doi.org/10.18632/oncotarget.3268
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| 9073-9085 |
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| Inhibition of the HER2YB1AR axis with Lapatinib synergistically enhances Enzalutamide antitumor efficacy in castration resistant prostate cancer |
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https://doi.org/10.18632/oncotarget.3602
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| 9086-9098 |
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| The SOX17/miR3715p/SOX2 axis inhibits EMT stem cell properties and metastasis in colorectal cancer |
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https://doi.org/10.18632/oncotarget.3603
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| 9099-9112 |
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| Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy |
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https://doi.org/10.18632/oncotarget.3272
|
| 9113-9124 |
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| MicroRNA155 expression is independently predictive of outcome in chordoma |
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https://doi.org/10.18632/oncotarget.3273
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| 9125-9139 |
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| By activating matrix metalloproteinase7 shear stress promotes chondrosarcoma cell motility invasion and lung colonization |
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https://doi.org/10.18632/oncotarget.3274
|
| 9140-9159 |
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| The long noncoding RNA HNF1AAS1 regulates proliferation and metastasis in lung adenocarcinoma |
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https://doi.org/10.18632/oncotarget.3247
|
| 9160-9172 |
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| ANO1 interacts with EGFR and correlates with sensitivity to EGFRtargeting therapy in head and neck cancer |
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https://doi.org/10.18632/oncotarget.3277
|
| 9173-9188 |
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| FLT3ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl1 pathway through STAT5 activation in acute myeloid leukemia |
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https://doi.org/10.18632/oncotarget.3279
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| 9189-9205 |
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| Mer receptor tyrosine kinase is frequently overexpressed in human nonsmall cell lung cancer confirming resistance to erlotinib |
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https://doi.org/10.18632/oncotarget.3280
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| 9206-9219 |
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| The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2 a potential tumor suppressor in the urinary bladder urothelial carcinoma |
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https://doi.org/10.18632/oncotarget.3312
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| 9220-9239 |
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| FBXW7mutated colorectal cancer cells exhibit aberrant expression of phosphorylatedp53 at Serine15 |
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https://doi.org/10.18632/oncotarget.3284
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| 9240-9256 |
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| miR340 suppresses glioblastoma multiforme |
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https://doi.org/10.18632/oncotarget.3288
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| 9257-9270 |
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| The mitochondrial carrier SLC25A10 regulates cancer cell growth |
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https://doi.org/10.18632/oncotarget.3375
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| 9271-9283 |
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| Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance |
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https://doi.org/10.18632/oncotarget.3252
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| 9284-9294 |
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| A pentacyclic triterpene natural product ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis |
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https://doi.org/10.18632/oncotarget.3261
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| 9295-9312 |
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| Upregulation of CD44 in the development of metastasis recurrence and drug resistance of ovarian cancer |
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https://doi.org/10.18632/oncotarget.3220
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| 9313-9326 |
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| Coinhibition of pololike kinase 1 and Aurora kinases promotes mitotic catastrophe |
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https://doi.org/10.18632/oncotarget.3313
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| 9327-9340 |
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| A novel smallform NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis |
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https://doi.org/10.18632/oncotarget.3322
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| 9341-9354 |
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| Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development |
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https://doi.org/10.18632/oncotarget.3323
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| 9355-9369 |
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| HPV16 E5 deregulates the autophagic process in human keratinocytes |
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https://doi.org/10.18632/oncotarget.3326
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| 9370-9386 |
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| Gut bacteria require neutrophils to promote mammary tumorigenesis |
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https://doi.org/10.18632/oncotarget.3328
|
| 9387-9396 |
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| CIP4 promotes metastasis in triplenegative breast cancer and is associated with poor patient prognosis |
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https://doi.org/10.18632/oncotarget.3351
|
| 9397-9408 |
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| Temporal regulation of HIF1 and NFκB in hypoxic hepatocarcinoma cells |
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https://doi.org/10.18632/oncotarget.3352
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| 9409-9419 |
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| PTPROmediated autophagy prevents hepatosteatosis and tumorigenesis |
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https://doi.org/10.18632/oncotarget.3353
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| 9420-9433 |
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| Heterogeneous chromosome 12p deletion is an independent adverse prognostic factor and resistant to bortezomibbased therapy in multiple myeloma |
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https://doi.org/10.18632/oncotarget.3319
|
| 9434-9444 |
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| MiR195 suppresses nonsmall cell lung cancer by targeting CHEK1 |
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https://doi.org/10.18632/oncotarget.3255
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| 9445-9456 |
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| miR211 suppresses hepatocellular carcinoma by downregulating SATB2 |
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https://doi.org/10.18632/oncotarget.3265
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| 9457-9466 |
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| Quantification of cellular viability by automated microscopy and flow cytometry |
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https://doi.org/10.18632/oncotarget.3266
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| 9467-9475 |
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| Lyn modulates Claudin2 expression and is a therapeutic target for breast cancer liver metastasis |
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https://doi.org/10.18632/oncotarget.3269
|
| 9476-9487 |
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| Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in nonHodgkin lymphoma |
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https://doi.org/10.18632/oncotarget.3378
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| 9488-9501 |
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| TRAILR2 promotes skeletal metastasis in a breast cancer xenograft mouse model |
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https://doi.org/10.18632/oncotarget.3321
|
| 9502-9516 |
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| Transcriptional coactivator TAZ sustains proliferation and tumorigenicity of neuroblastoma by targeting CTGF and PDGFβ |
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https://doi.org/10.18632/oncotarget.3367
|
| 9517-9530 |
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| Podoplaninexpressing cancerassociated fibroblasts inhibit small cell lung cancer growth |
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https://doi.org/10.18632/oncotarget.3371
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| 9531-9541 |
Clinical Research Papers
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| Prognostic value of monocyte and neutrophils to lymphocytes ratio in patients with metastatic soft tissue sarcoma |
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https://doi.org/10.18632/oncotarget.3283
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| 9542-9550 |
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| Serum thioredoxin is a diagnostic marker for hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.3314
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| 9551-9563 |
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| Polymorphism in onecarbon metabolism pathway affects survival of gastric cancer patients: Large and comprehensive study |
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https://doi.org/10.18632/oncotarget.3259
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| 9564-9576 |
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| Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways |
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https://doi.org/10.18632/oncotarget.3445
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| 9577-9591 |
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| Elevated serum CA724 levels predict poor prognosis in pancreatic adenocarcinoma after intensitymodulated radiation therapy |
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https://doi.org/10.18632/oncotarget.3562
|
| 9592-9599 |
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| Prognostic value of receptor conversion after neoadjuvant chemotherapy in breast cancer patients: a prospective observational study |
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https://doi.org/10.18632/oncotarget.3292
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| 9600-9611 |
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| Hypomethylation and upregulation of PD1 in T cells by azacytidine in MDS/AML patients: A rationale for combined targeting of PD1 and DNA methylation |
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https://doi.org/10.18632/oncotarget.3324
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| 9612-9626 |
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| Head and neck cancer subtypes with biological and clinical relevance: Metaanalysis of geneexpression data |
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https://doi.org/10.18632/oncotarget.3301
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| 9627-9642 |
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