VOLUME 6 (2015)
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About The Cover
Doxycycline targets mitochondrial biogenesis and DNA-repair, ultimately converging on ATP production and energy metabolism in cancer cells. See Lamb et al.
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Table of Contents
Editorial
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| YinandYang of mTORC1/C2 in Angelman syndrome mice |
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https://doi.org/10.18632/oncotarget.4298
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| 13844-13845 |
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| A nutritional perspective on cellular rejuvenation |
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https://doi.org/10.18632/oncotarget.4326
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| 13846-13847 |
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| Digesting dietary miRNA therapeutics |
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https://doi.org/10.18632/oncotarget.4357
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| 13848-13849 |
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| Δ113p53/Δ133p53: survival and integrity |
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https://doi.org/10.18632/oncotarget.4371
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| 13850-13851 |
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| Plant and animal organelles in cell death |
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https://doi.org/10.18632/oncotarget.4386
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| 13852-13853 |
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| Tumour modelling using viral vectors |
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https://doi.org/10.18632/oncotarget.4387
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| 13854-13855 |
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| Long tails short telomeres: Dyskeratosis congenita |
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https://doi.org/10.18632/oncotarget.4388
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| 13856-13857 |
Reviews: Gerotarget (Focus on Aging)
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| Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition |
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https://doi.org/10.18632/oncotarget.4030
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| 13858-13898 |
Reviews
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| Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened |
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https://doi.org/10.18632/oncotarget.4224
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| 13899-13913 |
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| MicroRNA expression and its implications for diagnosis and therapy of gallbladder cancer |
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https://doi.org/10.18632/oncotarget.4227
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| 13914-13921 |
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| DNA methylation and cognitive aging |
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https://doi.org/10.18632/oncotarget.4215
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| 13922-13932 |
Priority Research Papers
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| Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma–is it necessary? |
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https://doi.org/10.18632/oncotarget.4324
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| 13933-13945 |
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| miR181c associates with tumor relapse of high grade osteosarcoma |
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https://doi.org/10.18632/oncotarget.3539
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| 13946-13961 |
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| AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4EBP1 axis |
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https://doi.org/10.18632/oncotarget.3920
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| 13962-13977 |
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| βcatenin activation drives thymoma initiation and progression in mice |
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https://doi.org/10.18632/oncotarget.4368
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| 13978-13993 |
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| P73 tumor suppressor and its targets p21 and PUMA are required for madindarby canine kidney cell morphogenesis by maintaining an appropriate level of epithelial to mesenchymal transition |
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https://doi.org/10.18632/oncotarget.4374
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| 13994-14004 |
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| Doxycycline downregulates DNAPK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy |
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https://doi.org/10.18632/oncotarget.4159
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| 14005-14025 |
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| Soluble IL6R represents a miR34a target: potential implications for the recently identified IL6R/STAT3/miR34a feedback loop |
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https://doi.org/10.18632/oncotarget.4334
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| 14026-14032 |
Research Papers: Pathology
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| The indirect NMDAR inhibitor flupirtine induces sustained postischemic recovery neuroprotection and angioneurogenesis |
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https://doi.org/10.18632/oncotarget.4226
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| 14033-14044 |
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| Maintaining human fetal pancreatic stellate cell function and proliferation require β1 integrin and collagen I matrix interactions |
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https://doi.org/10.18632/oncotarget.4338
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| 14045-14059 |
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| Paroxysmal supraventricular tachycardia as first manifestation of right atrial hemangioma during endovascular treatment of intracranial arteriovenous fistulas |
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https://doi.org/10.18632/oncotarget.3781
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| 14060-14064 |
Research Papers: Gerotarget (Focus on Aging)
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| Involvement of cellular metabolism in agerelated LTP modifications in rat hippocampal slices |
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https://doi.org/10.18632/oncotarget.4188
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| 14065-14081 |
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| APOε2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study |
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https://doi.org/10.18632/oncotarget.4118
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| 14082-14091 |
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| Dynamic selfguiding analysis of Alzheimer’s disease |
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https://doi.org/10.18632/oncotarget.4221
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| 14092-14122 |
Research Papers: Immunology
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| NFκB p38 MAPK ERK1/2 mTOR STAT3 and increased glycolysis regulate stability of paricalcitol/dexamethasonegenerated tolerogenic dendritic cells in the inflammatory environment |
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https://doi.org/10.18632/oncotarget.4234
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| 14123-14138 |
Research Papers
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| A simplified interventional mapping system SIMS for the selection of combinations of targeted treatments in nonsmall cell lung cancer |
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https://doi.org/10.18632/oncotarget.3741
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| 14139-14152 |
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| miR221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases |
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https://doi.org/10.18632/oncotarget.3686
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| 14153-14164 |
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| CXCL16/CXCR6 chemokine signaling mediates breast cancer progression by pERK1/2dependent mechanisms |
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https://doi.org/10.18632/oncotarget.3690
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| 14165-14178 |
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| Infiltrating mast cells enhance prostate cancer invasion via altering LncRNAHOTAIR/PRC2androgen receptor ARMMP9 signals and increased stem/progenitor cell population |
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https://doi.org/10.18632/oncotarget.3651
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| 14179-14190 |
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| EFEMP1 promotes the migration and invasion of osteosarcoma via MMP2 with induction by AEG1 via NFκB signaling pathway |
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https://doi.org/10.18632/oncotarget.3691
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| 14191-14208 |
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| The association between PDL1 and EGFR status and the prognostic value of PDL1 in advanced nonsmall cell lung cancer patients treated with EGFRTKIs |
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https://doi.org/10.18632/oncotarget.3694
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| 14209-14219 |
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| Kras activation in p53deficient myoblasts results in highgrade sarcoma formation with impaired myogenic differentiation |
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https://doi.org/10.18632/oncotarget.3856
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| 14220-14232 |
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| Lemur Tyrosine Kinase 2 a novel target in prostate cancer therapy |
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https://doi.org/10.18632/oncotarget.3899
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| 14233-14246 |
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| Necrosis targeted radiotherapy with iodine131labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models |
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https://doi.org/10.18632/oncotarget.3679
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| 14247-14259 |
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| uPARtargeted multimodal tracer for pre and intraoperative imaging in cancer surgery |
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https://doi.org/10.18632/oncotarget.3680
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| 14260-14273 |
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| NKX21mediated p53 expression modulates lung adenocarcinoma progression via modulating IKKβ/NFκB activation |
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https://doi.org/10.18632/oncotarget.3695
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| 14274-14289 |
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| Deltex3like DTX3L stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway |
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https://doi.org/10.18632/oncotarget.3742
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| 14290-14299 |
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| Fibroblast surfaceassociated FGF2 promotes contactdependent colorectal cancer cell migration and invasion through FGFRSRC signaling and integrin αvβ5mediated adhesion |
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https://doi.org/10.18632/oncotarget.3883
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| 14300-14317 |
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| Trop2 is upregulated in invasive prostate cancer and displaces FAK from focal contacts |
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https://doi.org/10.18632/oncotarget.3960
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| 14318-14328 |
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| JAK2 inhibitor TG101348 overcomes erlotinibresistance in nonsmall cell lung carcinoma cells with mutated EGF receptor |
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https://doi.org/10.18632/oncotarget.3685
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| 14329-14343 |
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| Frequent amplification of AIB1 a critical oncogene modulating major signaling pathways is associated with poor survival in gastric cancer |
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https://doi.org/10.18632/oncotarget.3852
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| 14344-14359 |
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| Highly effective NK cells are associated with good prognosis in patients with metastatic prostate cancer |
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https://doi.org/10.18632/oncotarget.3965
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| 14360-14373 |
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| Ectopic expression of a novel CD22 splicevariant regulates survival and proliferation in malignant T cells from cutaneous T cell lymphoma CTCL patients |
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https://doi.org/10.18632/oncotarget.3720
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| 14374-14384 |
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| PUMA mediates the combinational therapy of 5FU and NVPBEZ235 in colon cancer |
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https://doi.org/10.18632/oncotarget.3775
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| 14385-14398 |
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| The EMTactivator ZEB1 induces bone metastasis associated genes including BMPinhibitors |
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https://doi.org/10.18632/oncotarget.3882
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| 14399-14412 |
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| Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases |
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https://doi.org/10.18632/oncotarget.3891
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| 14413-14427 |
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| WntC59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment |
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https://doi.org/10.18632/oncotarget.3982
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| 14428-14439 |
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| MicroRNA33amediated downregulation of Pim3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine |
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https://doi.org/10.18632/oncotarget.3885
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| 14440-14455 |
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| Pit1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment |
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https://doi.org/10.18632/oncotarget.3894
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| 14456-14471 |
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| Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in KRas mutated pancreatic and colon cancer cells |
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https://doi.org/10.18632/oncotarget.3991
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| 14472-14487 |
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| Reactive stroma component COL6A1 is upregulated in castrationresistant prostate cancer and promotes tumor growth |
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https://doi.org/10.18632/oncotarget.3697
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| 14488-14496 |
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| CJun recruits the NSL complex to regulate its target gene expression by modulating H4K16 acetylation and promoting the release of the repressive NuRD complex |
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https://doi.org/10.18632/oncotarget.3988
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| 14497-14506 |
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| Combined inhibition of Bcl2/BclxL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo |
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https://doi.org/10.18632/oncotarget.3993
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| 14507-14521 |
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| Destabilisation of dimeric 1433 proteins as a novel approach to anticancer therapeutics |
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https://doi.org/10.18632/oncotarget.3995
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| 14522-14536 |
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| Perioperative cerebral ischemia promote infiltrative recurrence in glioblastoma |
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https://doi.org/10.18632/oncotarget.3994
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| 14537-14544 |
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| Absolute quantification of cellfree microRNAs in cancer patients |
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https://doi.org/10.18632/oncotarget.3859
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| 14545-14555 |
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| Tumor promotion by γ and suppression by β nonmuscle actin isoforms |
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https://doi.org/10.18632/oncotarget.3989
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| 14556-14571 |
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| Lysinespecific demethylase LSD1/KDM1A and MYCN cooperatively repress tumor suppressor genes in neuroblastoma |
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https://doi.org/10.18632/oncotarget.3990
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| 14572-14583 |
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| Proteomic profiling of high risk medulloblastoma reveals functional biology |
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https://doi.org/10.18632/oncotarget.3927
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| 14584-14595 |
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| Endoplasmic reticulum targeting in Ewing’s sarcoma by the alkylphospholipid analog edelfosine |
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https://doi.org/10.18632/oncotarget.4053
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| 14596-14613 |
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| Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics |
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https://doi.org/10.18632/oncotarget.3786
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| 14614-14624 |
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| Comparison of the selective targeting efficacy of Salmonella typhimurium A1R and VNP20009 on the Lewis lung carcinoma in nude mice |
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https://doi.org/10.18632/oncotarget.3342
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| 14625-14631 |
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| RPPAbased protein profiling reveals eIF4G overexpression and 4EBP1 serine 65 phosphorylation as molecular events that correspond with a prosurvival phenotype in chronic lymphocytic leukemia |
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https://doi.org/10.18632/oncotarget.4104
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| 14632-14645 |
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| Role of TGFβ signaling in uterine carcinosarcoma |
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https://doi.org/10.18632/oncotarget.3711
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| 14646-14655 |
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| Dynamic treatment effect DTE curves reveal the mode of action for standard and experimental cancer therapies |
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https://doi.org/10.18632/oncotarget.4141
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| 14656-14668 |
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| IPP51 a chalcone acting as a microtubule inhibitor with in vivo antitumor activity against bladder carcinoma |
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https://doi.org/10.18632/oncotarget.4144
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| 14669-14686 |
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| Monocytes and macrophages implications for breast cancer migration and stem celllike activity and treatment |
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https://doi.org/10.18632/oncotarget.4189
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| 14687-14699 |
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| Assessment of folate receptorβ expression in human neoplastic tissues |
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https://doi.org/10.18632/oncotarget.3739
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| 14700-14709 |
Clinical Research Papers
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| Secondary bladder cancer after anticancer therapy for prostate cancer: reduced comorbidity after androgendeprivation therapy |
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https://doi.org/10.18632/oncotarget.3817
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| 14710-14719 |
Errata
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| Erratum: Clinical and biological significance of de novo CD5+ diffuse large Bcell lymphoma in Western countries |
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https://doi.org/10.18632/oncotarget.4464
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| 14720 |
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