VOLUME 6 (2015)
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Ectopic expression of 14q32-encoded miRNAs limits lung colonization of metastatic tumor cells. See Uppal et al.
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Table of Contents
Editorial
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| Nfkb1/p50 and mammalian aging |
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https://doi.org/10.18632/oncotarget.3405
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| 3471-3472 |
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| Nonmutational epigenomic structural variation in the transcriptome of cancer cells |
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https://doi.org/10.18632/oncotarget.3406
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| 3473-3474 |
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| Prelamin A and Oct1: a puzzle of aging |
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https://doi.org/10.18632/oncotarget.3422
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| 3475-3476 |
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| Dßhydroxybutyrate: an antiaging ketone body |
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https://doi.org/10.18632/oncotarget.3423
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| 3477-3478 |
Reviews
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| PD1 pathway inhibitors: The next generation of immunotherapy for advanced melanoma |
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https://doi.org/10.18632/oncotarget.2980
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| 3479-3492 |
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| The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3 |
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https://doi.org/10.18632/oncotarget.3051
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| 3493-3506 |
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| Roles of cMet and RON kinases in tumor progression and their potential as therapeutic targets |
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https://doi.org/10.18632/oncotarget.3420
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| 3507-3518 |
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| Bcl2 family proteins in breast development and cancer: could Mcl1 targeting overcome therapeutic resistance |
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https://doi.org/10.18632/oncotarget.2792
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| 3519-3530 |
Research Perspectives
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| Potential crosstalk between cofilin1 and EGFR pathways in cisplatin resistance of nonsmallcell lung cancer |
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https://doi.org/10.18632/oncotarget.3471
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| 3531-3539 |
Priority Research Papers
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| 14q32encoded microRNAs mediate an oligometastatic phenotype |
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https://doi.org/10.18632/oncotarget.2920
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| 3540-3552 |
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| Graphene oxide selectively targets cancer stem cells across multiple tumor types: Implications for nontoxic cancer treatment via “differentiationbased nanotherapy†|
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https://doi.org/10.18632/oncotarget.3348
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| 3553-3562 |
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| p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia |
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https://doi.org/10.18632/oncotarget.2969
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| 3563-3577 |
Research Papers: Gerotarget (Focus on Aging)
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| Trafficking protein particle complex 6A delta TRAPPC6AΔ is an extracellular plaqueforming protein in the brain |
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https://doi.org/10.18632/oncotarget.2876
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| 3578-3589 |
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| Plasmid DNAcoding p62 as a bone effective antiinflammatory/anabolic agent |
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https://doi.org/10.18632/oncotarget.2884
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| 3590-3599 |
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| Noncoding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival |
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https://doi.org/10.18632/oncotarget.2877
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| 3600-3612 |
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| The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts |
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https://doi.org/10.18632/oncotarget.2919
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| 3613-3626 |
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| DNA methylome and transcriptome sequencing in human ovarian granulosa cells links agerelated changes in gene expression to gene body methylation and 3’end GC density |
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https://doi.org/10.18632/oncotarget.2875
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| 3627-3643 |
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| Autophagy through 4EBP1 and AMPK regulates oxidative stressinduced premature senescence in auditory cells |
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https://doi.org/10.18632/oncotarget.2874
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| 3644-3655 |
Research Papers
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| Plasmin releases the antitumor peptide from the NC1 domain of collagen XIX |
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https://doi.org/10.18632/oncotarget.2849
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| 3656-3668 |
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| Notch3 functions as a regulator of cell selfrenewal by interacting with the βcatenin pathway in hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.2898
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| 3669-3679 |
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| PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation |
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https://doi.org/10.18632/oncotarget.2918
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| 3680-3693 |
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| Interleukin27 reeducates intratumoral myeloid cells and downregulates stemness genes in nonsmall cell lung cancer |
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https://doi.org/10.18632/oncotarget.2797
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| 3694-3708 |
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| Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stemlike cells |
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https://doi.org/10.18632/oncotarget.2888
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| 3709-3721 |
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| Oncoprotein mdig contributes to silicainduced pulmonary fibrosis by altering balance between Th17 and Treg T cells |
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https://doi.org/10.18632/oncotarget.2914
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| 3722-3736 |
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| Zfra activates memory Hyal2+ CD3 CD19 spleen cells to block cancer growth stemness and metastasis in vivo |
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https://doi.org/10.18632/oncotarget.2895
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| 3737-3751 |
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| CtBP2 is an independent prognostic marker that promotes GLI1 induced epithelialmesenchymal transition in hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.2915
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| 3752-3769 |
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| MicroRNA10b inhibition reduces E2F1mediated transcription and miR15/16 activity in glioblastoma |
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https://doi.org/10.18632/oncotarget.3009
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| 3770-3783 |
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| Protease nexin 1 induces apoptosis of prostate tumor cells through inhibition of Xchromosomelinked inhibitor of apoptosis protein |
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https://doi.org/10.18632/oncotarget.2921
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| 3784-3796 |
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| Vacuolar ATPase 'a2' isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer |
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https://doi.org/10.18632/oncotarget.2902
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| 3797-3810 |
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| EPI001 is a selective peroxisome proliferatoractivated receptorgamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer |
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https://doi.org/10.18632/oncotarget.2924
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| 3811-3824 |
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| NFkB signaling mediates acquired resistance after PARP inhibition |
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https://doi.org/10.18632/oncotarget.2868
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| 3825-3839 |
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| MicroRNA153 promotes Wnt/βcatenin activation in hepatocellular carcinoma through suppression of WWOX |
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https://doi.org/10.18632/oncotarget.2927
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| 3840-3847 |
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| NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNAPKcs inhibitor |
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https://doi.org/10.18632/oncotarget.2975
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| 3848-3860 |
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| Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells |
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https://doi.org/10.18632/oncotarget.2869
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| 3861-3873 |
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| Shed syndecan2 enhances tumorigenic activities of colon cancer cells |
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https://doi.org/10.18632/oncotarget.2885
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| 3874-3886 |
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| Inhibition of hedgehog signaling improves the anticarcinogenic effects of docetaxel in prostate cancer |
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https://doi.org/10.18632/oncotarget.2932
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| 3887-3903 |
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| Downregulation of microRNA23a suppresses prostate cancer metastasis by targeting the PAK6LIMK1 signaling pathway |
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https://doi.org/10.18632/oncotarget.2880
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| 3904-3917 |
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| Increase of miR199a5p by protoporphyrin IX a photocatalyzer directly inhibits E2F3 sensitizing mesenchymal tumor cells to anticancer agents |
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https://doi.org/10.18632/oncotarget.2928
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| 3918-3931 |
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| HeregulinHER3HER2 signaling promotes matrix metalloproteinasedependent bloodbrainbarrier transendothelial migration of human breast cancer cell lines |
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https://doi.org/10.18632/oncotarget.2846
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| 3932-3946 |
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| Identification of NDUFAF1 in mediating KRas induced mitochondrial dysfunction by a proteomic screening approach |
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https://doi.org/10.18632/oncotarget.2968
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| 3947-3962 |
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| Morphine promotes cancer stem cell properties contributing to chemoresistance in breast cancer |
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https://doi.org/10.18632/oncotarget.2894
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| 3963-3976 |
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| Tamoxifen improves cytopathic effect of oncolytic adenovirus in primary glioblastoma cells mediated through autophagy |
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https://doi.org/10.18632/oncotarget.2897
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| 3977-3987 |
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| miR34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/cMyc pathway |
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https://doi.org/10.18632/oncotarget.2905
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| 3988-4004 |
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| Cterminal domain of SMYD3 serves as a unique HSP90regulated motif in oncogenesis |
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https://doi.org/10.18632/oncotarget.2970
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| 4005-4019 |
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| Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model |
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https://doi.org/10.18632/oncotarget.3004
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| 4020-4035 |
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| Novel long noncoding RNAs are specific diagnostic and prognostic markers for prostate cancer |
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https://doi.org/10.18632/oncotarget.2879
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| 4036-4050 |
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| Adenovirus expressing dual cMetspecific shRNA exhibits potent antitumor effect through autophagic cell death accompanied by senescencelike phenotypes in glioblastoma cells |
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https://doi.org/10.18632/oncotarget.3018
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| 4051-4065 |
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| miR106b5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma |
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https://doi.org/10.18632/oncotarget.2926
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| 4066-4079 |
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| Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer |
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https://doi.org/10.18632/oncotarget.2977
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| 4080-4096 |
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| Multilevelanalysis identify a cisexpression quantitative trait locus associated with risk of renal cell carcinoma |
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https://doi.org/10.18632/oncotarget.3001
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| 4097-4109 |
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| p22phox confers resistance to cisplatin by blocking its entry into the nucleus |
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https://doi.org/10.18632/oncotarget.2893
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| 4110-4125 |
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| A novel orally active watersoluble Inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts |
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https://doi.org/10.18632/oncotarget.2798
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| 4126-4143 |
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| miR191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPβ |
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https://doi.org/10.18632/oncotarget.2864
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| 4144-4158 |
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| Simultaneous inhibition of deubiquitinating enzymes DUBs and autophagy synergistically kills breast cancer cells |
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https://doi.org/10.18632/oncotarget.2904
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| 4159-4170 |
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| SKI2162 an inhibitor of the TGFβ type I receptor ALK5 inhibits radiationinduced fibrosis in mice |
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https://doi.org/10.18632/oncotarget.2878
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| 4171-4179 |
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| Stagespecific prognostic biomarkers in melanoma |
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https://doi.org/10.18632/oncotarget.2907
|
| 4180-4189 |
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| Accumulation of FOXP3+Tcells in the tumor microenvironment is associated with an epithelialmesenchymaltransitiontype tumor budding phenotype and is an independent prognostic factor in surgically resected pancreatic ductal adenocarcinoma |
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https://doi.org/10.18632/oncotarget.2775
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| 4190-4201 |
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| RASSF10 suppresses colorectal cancer growth by activating P53 signaling and sensitizes colorectal cancer cell to docetaxel |
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https://doi.org/10.18632/oncotarget.2866
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| 4202-4213 |
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| Glycolytic metabolism influences global chromatin structure |
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https://doi.org/10.18632/oncotarget.2929
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| 4214-4225 |
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| Farnesoid X receptor associates with βcatenin and inhibits its activity in hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.2899
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| 4226-4238 |
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| WISP-1, a novel angiogenic regulator of the CCN family, promotes oral squamous cell carcinoma angiogenesis through VEGF-A expression |
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https://doi.org/10.18632/oncotarget.2978
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| 4239-4252 |
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| Mucin1 shifts Smad3 signaling from the tumorsuppressive pSmad3C/p21WAF1 pathway to the oncogenic pSmad3L/cMyc pathway by activating JNK in human hepatocellular carcinoma cells |
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https://doi.org/10.18632/oncotarget.2973
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| 4253-4265 |
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| Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth |
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https://doi.org/10.18632/oncotarget.2887
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| 4266-4273 |
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| Identification of PAM4 clivatuzumabreactive epitope on MUC5AC: A promising biomarker and therapeutic target for pancreatic cancer |
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https://doi.org/10.18632/oncotarget.2760
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| 4274-4285 |
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| Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 |
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https://doi.org/10.18632/oncotarget.3006
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| 4286-4298 |
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| PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects |
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https://doi.org/10.18632/oncotarget.3012
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| 4299-4314 |
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| eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling |
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https://doi.org/10.18632/oncotarget.3008
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| 4315-4329 |
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| Nuclearencoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of highgrade gliomas |
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https://doi.org/10.18632/oncotarget.3015
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| 4330-4344 |
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| GATA1 induces epithelialmesenchymal transition in breast cancer cells through PAK5 oncogenic signaling |
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https://doi.org/10.18632/oncotarget.2999
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| 4345-4356 |
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| Inhibition of ERK1/2 downregulates the Hippo/YAP signaling pathway in human NSCLC cells |
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https://doi.org/10.18632/oncotarget.2974
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| 4357-4368 |
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| CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4 |
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https://doi.org/10.18632/oncotarget.2976
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| 4369-4384 |
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| Progression of naive intraepithelial neoplasia genome to aggressive squamous cell carcinoma genome of uterine cervix |
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https://doi.org/10.18632/oncotarget.2981
|
| 4385-4393 |
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| IL32θ inhibits monocytic differentiation of leukemia cells by attenuating expression of transcription factor PU1 |
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https://doi.org/10.18632/oncotarget.3013
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| 4394-4405 |
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| HIF2α mediates hypoxiainduced LIF expression in human colorectal cancer cells |
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https://doi.org/10.18632/oncotarget.3017
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| 4406-4417 |
Clinical Research Papers
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| GHSR DNA hypermethylation is a common epigenetic alteration of high diagnostic value in a broad spectrum of cancers |
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https://doi.org/10.18632/oncotarget.2759
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| 4418-4427 |
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| Immunological response and overall survival in a subset of advanced renal cell carcinoma patients from a randomized phase 2/3 study of naptumomab estafenatox plus IFNα versus IFNα |
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https://doi.org/10.18632/oncotarget.2922
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| 4428-4439 |
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| Hepatocellular carcinoma in a large medical center of China over a 10year period: evolving therapeutic option and improving survival |
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https://doi.org/10.18632/oncotarget.2913
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| 4440-4450 |
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| RACK1 is a candidate gene associated with the prognosis of patients with early stage nonsmall cell lung cancer |
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https://doi.org/10.18632/oncotarget.2865
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| 4451-4466 |
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| Immunological data from cancer patients treated with Ad5/3 E2F Δ24 GMCSF suggests utility for tumor immunotherapy |
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https://doi.org/10.18632/oncotarget.2901
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| 4467-4481 |
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| Poor survival is associated with the methylated degree of Zincfinger protein 545 ZNF545 DNA promoter in gastric cancer |
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https://doi.org/10.18632/oncotarget.2916
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| 4482-4495 |
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| Safety and biodistribution of 111Inamatuximab in patients with mesothelin expressing cancers using single photon emission computed tomographycomputed tomography SPECTCT imaging |
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https://doi.org/10.18632/oncotarget.2883
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| 4496-4504 |
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| Circulation long noncoding RNAs act as biomarkers for predicting tumorigenesis and metastasis in hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.2934
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| 4505-4515 |
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| GOT1/AST1 expression status as a prognostic biomarker in pancreatic ductal adenocarcinoma |
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https://doi.org/10.18632/oncotarget.2799
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| 4516-4526 |
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| A Phase I trial of high dose gefitinib for patients with leptomeningeal metastases from nonsmall cell lung cancer |
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https://doi.org/10.18632/oncotarget.2886
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| 4527-4536 |
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| Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma |
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https://doi.org/10.18632/oncotarget.3005
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| 4537-4550 |
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