VOLUME 7 (2016)
Table of Contents
Editorial
Research Perspectives
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| Drug resistance in cancer: molecular evolution and compensatory proliferation |
|
https://doi.org/10.18632/oncotarget.7459
|
| 11746-11755 |
Priority Research Papers
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| Functional interactions of the cystine/glutamate antiporter CD44v and MUC1C oncoprotein in triplenegative breast cancer cells |
|
https://doi.org/10.18632/oncotarget.7598
|
| 11756-11769 |
|
| Cisacting elements in its 3′ UTR mediate posttranscriptional regulation of KRAS |
|
https://doi.org/10.18632/oncotarget.7599
|
| 11770-11784 |
|
| p73 promotes glioblastoma cell invasion by directly activating POSTN periostin expression |
|
https://doi.org/10.18632/oncotarget.7600
|
| 11785-11802 |
|
| Beneficial bacteria inhibit cachexia |
|
https://doi.org/10.18632/oncotarget.7730
|
| 11803-11816 |
|
| Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides |
|
https://doi.org/10.18632/oncotarget.7857
|
| 11817-11837 |
|
| Loss of p53mediated cellcycle arrest senescence and apoptosis promotes genomic instability and premature aging |
|
https://doi.org/10.18632/oncotarget.7864
|
| 11838-11849 |
Research Papers: Gerotarget (Focus on Aging)
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| The role of fineneedle aspiration in the thyroid nodules of elderly patients |
|
https://doi.org/10.18632/oncotarget.7643
|
| 11850-11859 |
|
| In normal aging ventricular system never attains pathological values of Evans’ index |
|
https://doi.org/10.18632/oncotarget.7644
|
| 11860-11863 |
|
| Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice |
|
https://doi.org/10.18632/oncotarget.7689
|
| 11864-11880 |
|
| The effect of Dserine administration on cognition and mood in older adults |
|
https://doi.org/10.18632/oncotarget.7691
|
| 11881-11888 |
|
| Loss of myocardial protection against myocardial infarction in middleaged transgenic mice overexpressing cardiac thioredoxin1 |
|
https://doi.org/10.18632/oncotarget.7726
|
| 11889-11898 |
|
| Rationale and design of the allogeneiC human mesenchymal stem cells hMSC in patients with aging fRAilTy via intravenoUS delivery CRATUS study: A phase I/II randomized blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty |
|
https://doi.org/10.18632/oncotarget.7727
|
| 11899-11912 |
|
| Agerelated alterations in blood and colonic dendritic cell properties |
|
https://doi.org/10.18632/oncotarget.7799
|
| 11913-11922 |
|
| Deletion of the γsecretase subunits Aph1B/C impairs memory and worsens the deficits of knockin mice modeling the Alzheimerlike familial Danish dementia |
|
https://doi.org/10.18632/oncotarget.7389
|
| 11923-11944 |
|
| AntiTNFα treatment modulates SASP and SASPrelated microRNAs in endothelial cells and in circulating angiogenic cells |
|
https://doi.org/10.18632/oncotarget.7858
|
| 11945-11958 |
|
| Accelerated geroncogenesis in hereditary breastovarian cancer syndrome |
|
https://doi.org/10.18632/oncotarget.7867
|
| 11959-11971 |
|
| Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging |
|
https://doi.org/10.18632/oncotarget.7863
|
| 11972-11983 |
Research Papers: Pathology
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| CCR5 deficiency accelerates lipopolysaccharideinduced astrogliosis amyloidbeta deposit and impaired memory function |
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https://doi.org/10.18632/oncotarget.7453
|
| 11984-11999 |
|
| Ectopic mineralization of cartilage and collagenrich tendons and ligaments in Enpp1asj2J mice |
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https://doi.org/10.18632/oncotarget.7455
|
| 12000-12009 |
|
| CD226 reduces endothelial cell glucose uptake under hyperglycemic conditions with inflammation in type 2 diabetes mellitus |
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https://doi.org/10.18632/oncotarget.7505
|
| 12010-12023 |
|
| CD274/PDL1 gene amplification and PDL1 protein expression are common events in squamous cell carcinoma of the oral cavity |
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https://doi.org/10.18632/oncotarget.7593
|
| 12024-12034 |
|
| REST alleviates neurotoxic prion peptideinduced synaptic abnormalities neurofibrillary degeneration and neuronal death partially via LRP6mediated Wntβcatenin signaling |
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https://doi.org/10.18632/oncotarget.7640
|
| 12035-12052 |
|
| Elevated expression of HIFlα in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia |
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https://doi.org/10.18632/oncotarget.7641
|
| 12053-12062 |
|
| GDF11/BMP11 activates both smad1/5/8 and smad2/3 signals but shows no significant effect on proliferation and migration of human umbilical vein endothelial cells |
|
https://doi.org/10.18632/oncotarget.7642
|
| 12063-12074 |
|
| Melatonin protects skin keratinocyte from hydrogen peroxidemediated cell death via the SIRT1 pathway |
|
https://doi.org/10.18632/oncotarget.7679
|
| 12075-12088 |
|
| Lowdose tacrolimus combined with donorderived mesenchymal stem cells after renal transplantation: a prospective nonrandomized study |
|
https://doi.org/10.18632/oncotarget.7725
|
| 12089-12101 |
|
| Biological outcome and mapping of total factor cascades in response to HIF induction during regenerative angiogenesis |
|
https://doi.org/10.18632/oncotarget.7728
|
| 12102-12120 |
|
| Decellularized allogeneic intervertebral disc: natural biomaterials for regenerating disc degeneration |
|
https://doi.org/10.18632/oncotarget.7735
|
| 12121-12136 |
|
| Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression |
|
https://doi.org/10.18632/oncotarget.7763
|
| 12137-12149 |
|
| PGC1α overexpression protects against aldosteroneinduced podocyte depletion: role of mitochondria |
|
https://doi.org/10.18632/oncotarget.7859
|
| 12150-12162 |
Research Papers: Immunology
|
| Human naïve regulatory Tcells feature high steadystate turnover and are maintained by IL7 |
|
https://doi.org/10.18632/oncotarget.7512
|
| 12163-12175 |
|
| A biodegradable killer microparticle to selectively deplete antigenspecific T cells in vitro and in vivo |
|
https://doi.org/10.18632/oncotarget.7519
|
| 12176-12190 |
|
| Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice |
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https://doi.org/10.18632/oncotarget.7687
|
| 12191-12205 |
|
| The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells |
|
https://doi.org/10.18632/oncotarget.7723
|
| 12206-12221 |
|
| The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B1 |
|
https://doi.org/10.18632/oncotarget.7731
|
| 12222-12234 |
|
| A bovine herpesvirus 1 pUL51 deletion mutant shows impaired viral growth in vitro and reduced virulence in rabbits |
|
https://doi.org/10.18632/oncotarget.7771
|
| 12235-12253 |
Research Papers: Autophagy and Cell Death
|
| Endoplasmic reticulum stressmediated induction of SESTRIN 2 potentiates cell survival |
|
https://doi.org/10.18632/oncotarget.7601
|
| 12254-12266 |
Research Papers: Chromosome
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| Novel Mad2targeting miR4933p controls mitotic fidelity and cancer cells’ sensitivity to paclitaxel |
|
https://doi.org/10.18632/oncotarget.7860
|
| 12267-12285 |
Reviews: Autophagy and Cell Death
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| Autophagy: a decisive process for stemness |
|
https://doi.org/10.18632/oncotarget.7766
|
| 12286-12288 |
Reviews
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| ALK and ROS1 as targeted therapy paradigms and clinical implications to overcome crizotinib resistance |
|
https://doi.org/10.18632/oncotarget.6935
|
| 12289-12304 |
|
| CRISPR/Cas9 and cancer targets: future possibilities and present challenges |
|
https://doi.org/10.18632/oncotarget.7104
|
| 12305-12317 |
|
| Stereotactic radiosurgery SRS in the modern management of patients with brain metastases |
|
https://doi.org/10.18632/oncotarget.7131
|
| 12318-12330 |
Research Papers
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| Nuclear localization of the caspase3cleaved form of p73 in anoikis |
|
https://doi.org/10.18632/oncotarget.6329
|
| 12331-12343 |
|
| A fully human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts |
|
https://doi.org/10.18632/oncotarget.7111
|
| 12344-12358 |
|
| Clonal relationships in recurrent Bcell lymphomas |
|
https://doi.org/10.18632/oncotarget.7132
|
| 12359-12371 |
|
| SOX2 boosts major tumor progression genes in prostate cancer and is a functional biomarker of lymph node metastasis |
|
https://doi.org/10.18632/oncotarget.6029
|
| 12372-12385 |
|
| NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition |
|
https://doi.org/10.18632/oncotarget.7157
|
| 12386-12392 |
|
| Angiomotin promotes renal epithelial and carcinoma cell proliferation by retaining the nuclear YAP |
|
https://doi.org/10.18632/oncotarget.7161
|
| 12393-12403 |
|
| The mechanism of acquired resistance to irreversible EGFR tyrosine kinase inhibitorafatinib in lung adenocarcinoma patients |
|
https://doi.org/10.18632/oncotarget.7189
|
| 12404-12413 |
|
| Circulating miR21 miR378 and miR940 increase in response to an acute exhaustive exercise in chronic heart failure patients |
|
https://doi.org/10.18632/oncotarget.6966
|
| 12414-12425 |
|
| Addiction of lung cancer cells to GOF p53 is promoted by upregulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter |
|
https://doi.org/10.18632/oncotarget.6998
|
| 12426-12446 |
|
| PP2A inhibition with LB100 enhances cisplatin cytotoxicity and overcomes cisplatin resistance in medulloblastoma cells |
|
https://doi.org/10.18632/oncotarget.6970
|
| 12447-12463 |
|
| Inhibition of OGlcNAc transferase activity reprograms prostate cancer cell metabolism |
|
https://doi.org/10.18632/oncotarget.7039
|
| 12464-12476 |
|
| Therapeutic response and side effects of repeated radioligand therapy with 177LuPSMADKFZ617 of castrateresistant metastatic prostate cancer |
|
https://doi.org/10.18632/oncotarget.7245
|
| 12477-12488 |
|
| Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy |
|
https://doi.org/10.18632/oncotarget.7273
|
| 12489-12504 |
|
| Clinical and biological significance of HAX1 overexpression in nasopharyngeal carcinoma |
|
https://doi.org/10.18632/oncotarget.7274
|
| 12505-12524 |
|
| Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBVrelated hepatocellular carcinoma: a metaanalysis |
|
https://doi.org/10.18632/oncotarget.7123
|
| 12525-12536 |
|
| Rad18 is required for functional interactions between FANCD2 BRCA2 and Rad51 to repair DNA topoisomerase 1poisons induced lesions and promote fork recovery |
|
https://doi.org/10.18632/oncotarget.7247
|
| 12537-12553 |
|
| Mutant p53 protects ETS2 from noncanonical COP1/DET1 dependent degradation |
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https://doi.org/10.18632/oncotarget.7275
|
| 12554-12567 |
|
| Inverse agonist of estrogenrelated receptor α suppresses the growth of triple negative breast cancer cells through ROS generation and interaction with multiple cell signaling pathways |
|
https://doi.org/10.18632/oncotarget.7276
|
| 12568-12581 |
|
| Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma |
|
https://doi.org/10.18632/oncotarget.7179
|
| 12582-12597 |
|
| Characterization of long noncoding RNAassociated ceRNA network to reveal potential prognostic lncRNA biomarkers in human ovarian cancer |
|
https://doi.org/10.18632/oncotarget.7181
|
| 12598-12611 |
|
| Exploiting machine learning for predicting skeletalrelated events in cancer patients with bone metastases |
|
https://doi.org/10.18632/oncotarget.7278
|
| 12612-12622 |
|
| Expression of the bitter receptor T2R38 in pancreatic cancer: localization in lipid droplets and activation by a bacteriaderived quorumsensing molecule |
|
https://doi.org/10.18632/oncotarget.7206
|
| 12623-12632 |
|
| Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis |
|
https://doi.org/10.18632/oncotarget.7279
|
| 12633-12650 |
|
| Androgens downregulate miR21 expression in breast cancer cells underlining the protective role of androgen receptor |
|
https://doi.org/10.18632/oncotarget.7207
|
| 12651-12661 |
|
| Effectiveness of the Monte Carlo method in stereotactic radiation therapy applied to quasihomogenous brain tumors |
|
https://doi.org/10.18632/oncotarget.7280
|
| 12662-12671 |
|
| miR21 expression and clinical outcome in locally advanced pancreatic cancer: exploratory analysis of the pancreatic cancer Erbitux radiotherapy and UFT PERU trial |
|
https://doi.org/10.18632/oncotarget.7208
|
| 12672-12681 |
|
| Arsenic trioxide inhibits glioma cell growth through induction of telomerase displacement and telomere dysfunction |
|
https://doi.org/10.18632/oncotarget.7259
|
| 12682-12692 |
|
| MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10 |
|
https://doi.org/10.18632/oncotarget.7281
|
| 12693-12703 |
|
| The relationship between EZH2 expression and microRNA31 in colorectal cancer and the role in evolution of the serrated pathway |
|
https://doi.org/10.18632/oncotarget.7260
|
| 12704-12717 |
|
| Regression/Eradication of gliomas in mice by a systemicallydeliverable ATF5 dominantnegative peptide |
|
https://doi.org/10.18632/oncotarget.7212
|
| 12718-12730 |
|
| miR451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma |
|
https://doi.org/10.18632/oncotarget.7262
|
| 12731-12747 |
|
| Classification of large circulating tumor cells isolated with ultrahigh throughput microfluidic Vortex technology |
|
https://doi.org/10.18632/oncotarget.7220
|
| 12748-12760 |
|
| High Mobility Group A2 protects cancer cells against telomere dysfunction |
|
https://doi.org/10.18632/oncotarget.6938
|
| 12761-12782 |
|
| Tumortargeting Salmonella typhimurium A1R in combination with doxorubicin eradicate soft tissue sarcoma in a patientderived orthotopic xenograft PDOX model |
|
https://doi.org/10.18632/oncotarget.7226
|
| 12783-12790 |
|
| Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo |
|
https://doi.org/10.18632/oncotarget.7302
|
| 12791-12805 |
|
| Association of rituximab with graphene oxide confers direct cytotoxicity for CD20positive lymphoma cells |
|
https://doi.org/10.18632/oncotarget.7230
|
| 12806-12822 |
|
| G proteincoupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells |
|
https://doi.org/10.18632/oncotarget.7313
|
| 12823-12839 |
|
| Induction of cancer testis antigen expression in circulating acute myeloid leukemia blasts following hypomethylating agent monotherapy |
|
https://doi.org/10.18632/oncotarget.7326
|
| 12840-12856 |
|
| Honokiol bisdichloroacetate Honokiol DCA demonstrates activity in vemurafenibresistant melanoma in vivo |
|
https://doi.org/10.18632/oncotarget.7289
|
| 12857-12868 |
|
| SREBP2 promotes stem celllike properties and metastasis by transcriptional activation of cMyc in prostate cancer |
|
https://doi.org/10.18632/oncotarget.7331
|
| 12869-12884 |
|
| Decision aid on breast cancer screening reduces attendance rate: results of a largescale randomized controlled study by the DECIDEO group |
|
https://doi.org/10.18632/oncotarget.7332
|
| 12885-12892 |
|
| MLN8237: A dual inhibitor of aurora A and B in soft tissue sarcomas |
|
https://doi.org/10.18632/oncotarget.7335
|
| 12893-12903 |
|
| Serum metabolomic profiling facilitates the noninvasive identification of metabolic biomarkers associated with the onset and progression of nonsmall cell lung cancer |
|
https://doi.org/10.18632/oncotarget.7354
|
| 12904-12916 |
|
| A novel small molecule STAT3 inhibitor LY5 inhibits cell viability colony formation and migration of colon and liver cancer cells |
|
https://doi.org/10.18632/oncotarget.7338
|
| 12917-12926 |
|
| Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy |
|
https://doi.org/10.18632/oncotarget.7340
|
| 12927-12936 |
|
| MicroRNA138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl2interacting mediator BIM |
|
https://doi.org/10.18632/oncotarget.7346
|
| 12937-12950 |
|
| Targeting the p53MDM2 interaction by the smallmolecule MDM2 antagonist Nutlin3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients |
|
https://doi.org/10.18632/oncotarget.7339
|
| 12951-12961 |
|
| Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9induced mutagenesis in murine zygotes |
|
https://doi.org/10.18632/oncotarget.7341
|
| 12962-12974 |
|
| Multikinase inhibitors can associate with heat shock proteins through their NH2termini by which they suppress chaperone function |
|
https://doi.org/10.18632/oncotarget.7349
|
| 12975-12996 |
|
| Osteopontin promotes epithelialmesenchymal transition of hepatocellular carcinoma through regulating vimentin |
|
https://doi.org/10.18632/oncotarget.7016
|
| 12997-13012 |
|
| Prognostic relevance of HER2/neu in acute lymphoblastic leukemia and induction of NK cell reactivity against primary ALL blasts by trastuzumab |
|
https://doi.org/10.18632/oncotarget.7344
|
| 13013-13030 |
|
| Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme |
|
https://doi.org/10.18632/oncotarget.7366
|
| 13031-13046 |
|
| LncRNAs as new biomarkers to differentiate triple negative breast cancer from nontriple negative breast cancer |
|
https://doi.org/10.18632/oncotarget.7509
|
| 13047-13059 |
|
| Tumor CTLA4 overexpression predicts poor survival in patients with nasopharyngeal carcinoma |
|
https://doi.org/10.18632/oncotarget.7421
|
| 13060-13068 |
|
| Validation of a preclinical model for assessment of drug efficacy in melanoma |
|
https://doi.org/10.18632/oncotarget.7541
|
| 13069-13081 |
|
| Development of 89ZrOntuxizumab for in vivo TEM1/endosialin PET applications |
|
https://doi.org/10.18632/oncotarget.7552
|
| 13082-13092 |
|
| The human 2B4 and NTBA receptors bind the influenza viral hemagglutinin and costimulate NK cell cytotoxicity |
|
https://doi.org/10.18632/oncotarget.7597
|
| 13093-13105 |
|
| The SOX11 transcription factor is a critical regulator of basallike breast cancer growth invasion and basallike gene expression |
|
https://doi.org/10.18632/oncotarget.7437
|
| 13106-13121 |
|
| AEG1/MTDHactivated autophagy enhances human malignant glioma susceptibility to TGFβ1triggered epithelialmesenchymal transition |
|
https://doi.org/10.18632/oncotarget.7536
|
| 13122-13138 |
|
| miR194 inhibits the proliferation invasion migration and enhances the chemosensitivity of nonsmall cell lung cancer cells by targeting forkhead box A1 protein |
|
https://doi.org/10.18632/oncotarget.7545
|
| 13139-13152 |
|
| Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer |
|
https://doi.org/10.18632/oncotarget.7549
|
| 13153-13166 |
|
| Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma |
|
https://doi.org/10.18632/oncotarget.7534
|
| 13167-13181 |
|
| Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment |
|
https://doi.org/10.18632/oncotarget.7537
|
| 13182-13196 |
|
| PARP activation promotes nuclear AID accumulation in lymphoma cells |
|
https://doi.org/10.18632/oncotarget.7603
|
| 13197-13208 |
Clinical Research Papers
|
| Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by postoperative trastuzumab for patients with HER2positive breast cancer |
|
https://doi.org/10.18632/oncotarget.4801
|
| 13209-13220 |
|
| Efficacy and toxicity of bevacizumab in recurrent ovarian disease: an update metaanalysis on phase III trials |
|
https://doi.org/10.18632/oncotarget.6507
|
| 13221-13227 |
|
| Marital status independently predicts gastric cancer survival after surgical resectionan analysis of the SEER database |
|
https://doi.org/10.18632/oncotarget.7107
|
| 13228-13235 |
|
| Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment |
|
https://doi.org/10.18632/oncotarget.7451
|
| 13236-13247 |
|
| Computed tomography texture analysis to facilitate therapeutic decision making in hepatocellular carcinoma |
|
https://doi.org/10.18632/oncotarget.7467
|
| 13248-13259 |
Case Reports
|
| Targeting the PD1 pathway in patients with relapsed classic Hodgkin lymphoma following allogeneic stem cell transplant is safe and effective |
|
https://doi.org/10.18632/oncotarget.7177
|
| 13260-13264 |
|
| Acquiredresistance of bevacizumab treatment for radiation brain necrosis: a case report |
|
https://doi.org/10.18632/oncotarget.7724
|
| 13265-13268 |
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