VOLUME 8 (2017)
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About The Cover
The cover for issue 27 of Oncotarget features Figure 4A, "Loss of TMEM192 does not impair lysosomal function in TMEM192-deficient murine embryonic fibroblasts (MEFs)," from Nguyen, et al.
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Table of Contents
News
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| Sphingosine kinase 2 and multiple myeloma |
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https://doi.org/10.18632/oncotarget.17420
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| 43596-43597 |
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| Olaparib and somatic BRCA mutations |
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https://doi.org/10.18632/oncotarget.18419
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| 43598-43599 |
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| T315I+ tyrosinekinase independent CML cells resistance |
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https://doi.org/10.18632/oncotarget.18573
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| 43600-43601 |
Priority Research Papers
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| Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress |
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https://doi.org/10.18632/oncotarget.17115
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| 43602-43616 |
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| Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptindeficient APP/PS1 mice |
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https://doi.org/10.18632/oncotarget.17116
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| 43617-43634 |
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| Functional characterization of the lysosomal membrane protein TMEM192 in mice |
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https://doi.org/10.18632/oncotarget.17514
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| 43635-43652 |
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| Biological and clinical evidence for somatic mutations in BRCA1 and BRCA2 as predictive markers for olaparib response in highgrade serous ovarian cancers in the maintenance setting |
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https://doi.org/10.18632/oncotarget.17613
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| 43653-43661 |
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| Targeting BCRABL+ stem/progenitor cells and BCRABLT315I mutant cells by effective inhibition of the BCRABLTyr177GRB2 complex |
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https://doi.org/10.18632/oncotarget.18216
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| 43662-43677 |
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| Biological specificity of CDK4/6 inhibitors: dose response relationship in vivo signaling and composite response signature |
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https://doi.org/10.18632/oncotarget.18435
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| 43678-43691 |
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| Mitochondrial ASncmtRNA1 and ASncmtRNA2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model |
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https://doi.org/10.18632/oncotarget.18460
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| 43692-43708 |
Research Papers: Gerotarget (Focus on Aging)
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| The protective effect of Epimedii Folium and Curculiginis Rhizoma on Alzheimer’s disease by the inhibitions of NFκB/MAPK pathway and NLRP3 inflammasome |
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https://doi.org/10.18632/oncotarget.12574
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| 43709-43720 |
Research Papers
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| Updated metaanalysis of the role of APOE ε2/ε3/ε4 alleles in frontotemporal lobar degeneration |
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https://doi.org/10.18632/oncotarget.17341
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| 43721-43732 |
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| Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway |
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https://doi.org/10.18632/oncotarget.16376
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| 43733-43751 |
|
| Wholeexome sequencing identified genetic risk factors for asparaginaserelated complications in childhood ALL patients |
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https://doi.org/10.18632/oncotarget.17959
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| 43752-43767 |
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| LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let7a in cervical cancer cells |
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https://doi.org/10.18632/oncotarget.10844
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| 43768-43781 |
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| Recombinant TATBMI1 fusion protein induces ex vivo expansion of human umbilical cord bloodderived hematopoietic stem cells |
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https://doi.org/10.18632/oncotarget.15156
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| 43782-43798 |
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| Resveratrol alleviates FFA and CCl4 induced apoptosis in HepG2 cells via restoring endoplasmic reticulum stress |
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https://doi.org/10.18632/oncotarget.16460
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| 43799-43809 |
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| inFRank: a rankingbased identification of influential genes in biological networks |
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https://doi.org/10.18632/oncotarget.11878
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| 43810-43821 |
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| Rabies viruses leader RNA interacts with host Hsc70 and inhibits virus replication |
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https://doi.org/10.18632/oncotarget.16517
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| 43822-43837 |
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| Cell cycle protein Bora serves as a novel poor prognostic factor in multiple adenocarcinomas |
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https://doi.org/10.18632/oncotarget.16631
|
| 43838-43852 |
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| Tumor suppressor BLU promotes TRAILinduced apoptosis by downregulating NFκB signaling in nasopharyngeal carcinoma |
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https://doi.org/10.18632/oncotarget.14126
|
| 43853-43865 |
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| Development of diagnostic SCAR markers for genomic DNA amplifications in breast carcinoma by DNA cloning of highGC RAMPPCR fragments |
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https://doi.org/10.18632/oncotarget.16704
|
| 43866-43877 |
|
| Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR1295p sponge and is used as a novel biomarker for hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.16709
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| 43878-43888 |
|
| MDI 301 a synthetic retinoid depressed levels of matrix metalloproteinases and oxidative stress in diabetic dermal fibroblasts |
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https://doi.org/10.18632/oncotarget.16803
|
| 43889-43896 |
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| miRNA1246 induces proinflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A |
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https://doi.org/10.18632/oncotarget.14915
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| 43897-43914 |
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| A metaanalysis of HLA peptidome composition in different hematological entities: entityspecific dividing lines and panleukemia antigens |
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https://doi.org/10.18632/oncotarget.14918
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| 43915-43924 |
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| Risk of hepatitis C virus related hepatocellular carcinoma between subjects with spontaneous and treatmentinduced viral clearance |
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https://doi.org/10.18632/oncotarget.14937
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| 43925-43933 |
|
| Exomebased genomewide association study and risk assessment using genetic risk score to prostate cancer in the Korean population |
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https://doi.org/10.18632/oncotarget.16540
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| 43934-43943 |
|
| Circulating asymmetric dimethylarginine and the risk of preeclampsia: a metaanalysis based on 1338 participants |
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https://doi.org/10.18632/oncotarget.16543
|
| 43944-43952 |
|
| SNORD47 a box C/D snoRNA suppresses tumorigenesis in glioblastoma |
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https://doi.org/10.18632/oncotarget.16693
|
| 43953-43966 |
|
| Exploring the key genes and pathways in enchondromas using a gene expression microarray |
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https://doi.org/10.18632/oncotarget.16700
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| 43967-43977 |
|
| Clinical verification of plasma messenger RNA as novel noninvasive biomarker identified through bioinformatics analysis for lung cancer |
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https://doi.org/10.18632/oncotarget.16701
|
| 43978-43989 |
|
| Variant 2 of KIAA0101 antagonizing its oncogenic variant 1 might be a potential therapeutic strategy in hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.16702
|
| 43990-44003 |
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| Radioimmunotherapy for CD133+ colonic cancer stem cells inhibits tumor development in nude mice |
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https://doi.org/10.18632/oncotarget.16868
|
| 44004-44014 |
|
| Survival benefit of glioblastoma patients after FDA approval of temozolomide concomitant with radiation and bevacizumab: A populationbased study |
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https://doi.org/10.18632/oncotarget.17054
|
| 44015-44031 |
|
| Nanopulse stimulation NPS ablate tumors and inhibit lung metastasis on both canine spontaneous osteosarcoma and murine transplanted hepatocellular carcinoma with high metastatic potential |
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https://doi.org/10.18632/oncotarget.17178
|
| 44032-44039 |
|
| The combination of prostate imaging reporting and data system version 2 PIRADS v2 and periprostatic fat thickness on multiparametric MRI to predict the presence of prostate cancer |
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https://doi.org/10.18632/oncotarget.17182
|
| 44040-44049 |
|
| Circulating miR21 serves as a serum biomarker for hepatocellular carcinoma and correlated with distant metastasis |
|
https://doi.org/10.18632/oncotarget.17211
|
| 44050-44058 |
|
| Simultaneous in vitro generation of CD8 and CD4 T cells specific to three universal tumor associated antigens of WT1 survivin and TERT and adoptive T cell transfer for the treatment of acute myeloid leukemia |
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https://doi.org/10.18632/oncotarget.17212
|
| 44059-44072 |
|
| Olaparib in combination with irinotecan cisplatin and mitomycin C in patients with advanced pancreatic cancer |
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https://doi.org/10.18632/oncotarget.17237
|
| 44073-44081 |
|
| POU2F1 overexpression correlates with poor prognoses and promotes cell growth and epithelialtomesenchymal transition in hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.17296
|
| 44082-44095 |
|
| Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer |
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https://doi.org/10.18632/oncotarget.17307
|
| 44096-44107 |
|
| Modulation of goat monocyte function by HCcyst2 a secreted cystatin from Haemonchus contortus |
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https://doi.org/10.18632/oncotarget.17308
|
| 44108-44120 |
|
| A phase II trial of regorafenib in patients with metastatic and/or a unresectable gastrointestinal stromal tumor harboring secondary mutations of exon 17 |
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https://doi.org/10.18632/oncotarget.17310
|
| 44121-44130 |
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| Radium223 for primary bone metastases in patients with hormonesensitive prostate cancer after radical prostatectomy |
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https://doi.org/10.18632/oncotarget.17311
|
| 44131-44140 |
|
| Differentially expressed proteins in glioblastoma multiforme identified with a nanobodybased antiproteome approach and confirmed by OncoFinder as possible tumorclass predictive biomarker candidates |
|
https://doi.org/10.18632/oncotarget.17390
|
| 44141-44158 |
|
| Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth |
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https://doi.org/10.18632/oncotarget.17395
|
| 44159-44170 |
|
| Knockdown of PKM2 and GLS1 expression can significantly reverse oxaliplatinresistance in colorectal cancer cells |
|
https://doi.org/10.18632/oncotarget.17396
|
| 44171-44185 |
|
| IRF5 is associated with adverse postoperative prognosis of patients with nonmetastatic clear cell renal cell carcinoma |
|
https://doi.org/10.18632/oncotarget.17777
|
| 44186-44194 |
|
| DDX11AS1 as potential therapy targets for human hepatocellular carcinoma |
|
https://doi.org/10.18632/oncotarget.17409
|
| 44195-44202 |
|
| Risk of cancer in patients with heart failure who use digoxin: a 10year followup study and cellbased verification |
|
https://doi.org/10.18632/oncotarget.17410
|
| 44203-44216 |
|
| Urinary exosomes reveal protein signatures in hypertensive patients with albuminuria |
|
https://doi.org/10.18632/oncotarget.17787
|
| 44217-44231 |
|
| Synergistic targeting of malignant pleural mesothelioma cells by MDM2 inhibitors and TRAIL agonists |
|
https://doi.org/10.18632/oncotarget.17790
|
| 44232-44241 |
|
| An herbal formula attenuates collageninduced arthritis via inhibition of JAK2STAT3 signaling and regulation of Th17 cells in mice |
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https://doi.org/10.18632/oncotarget.17797
|
| 44242-44254 |
|
| Structure based discovery of clomifene as a potent inhibitor of cancerassociated mutant IDH1 |
|
https://doi.org/10.18632/oncotarget.17464
|
| 44255-44265 |
|
| Leflunomide/teriflunomide inhibit EpsteinBarr virus EBVinduced lymphoproliferative disease and lytic viral replication |
|
https://doi.org/10.18632/oncotarget.17863
|
| 44266-44280 |
|
| The optimization of cell therapy by combinational application with apicidintreated mesenchymal stem cells after myocardial infarction |
|
https://doi.org/10.18632/oncotarget.17471
|
| 44281-44294 |
|
| Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS5584 in preclinical models of pancreatic cancer |
|
https://doi.org/10.18632/oncotarget.17869
|
| 44295-44311 |
|
| The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer |
|
https://doi.org/10.18632/oncotarget.17871
|
| 44312-44325 |
|
| Increased expression of long noncoding RNA CCEPR is associated with poor prognosis and promotes tumorigenesis in urothelial bladder carcinoma |
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https://doi.org/10.18632/oncotarget.17872
|
| 44326-44334 |
|
| EGF receptor lysosomal degradation is delayed in the cells stimulated with EGFQuantum dot bioconjugate but earlier key events of endocytic degradative pathway are similar to that of native EGF |
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https://doi.org/10.18632/oncotarget.17873
|
| 44335-44350 |
|
| Impact of chronic unpredicted mild stressinduced depression on repaglinide fate via glucocorticoid signaling pathway |
|
https://doi.org/10.18632/oncotarget.17874
|
| 44351-44365 |
|
| New interleukin15 superagonist IL15SA significantly enhances graftversustumor activity |
|
https://doi.org/10.18632/oncotarget.17875
|
| 44366-44378 |
|
| Histone modifications affect differential regulation of TGFβ induced NADPH oxidase 4 NOX4 by wildtype and mutant p53 |
|
https://doi.org/10.18632/oncotarget.17892
|
| 44379-44397 |
|
| Methylation regulates HEY1 expression in glioblastoma |
|
https://doi.org/10.18632/oncotarget.17897
|
| 44398-44409 |
|
| Dexmedetomidine alleviates lipopolysaccharideinduced lung injury in Wistar rats |
|
https://doi.org/10.18632/oncotarget.17899
|
| 44410-44417 |
|
| Characterization of tumorassociated Tlymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma |
|
https://doi.org/10.18632/oncotarget.17901
|
| 44418-44433 |
|
| Socioeconomic status is associated with global diabetes prevalence |
|
https://doi.org/10.18632/oncotarget.17902
|
| 44434-44439 |
|
| FGF21 functions as a sensitive biomarker of APAPtreated patients and mice |
|
https://doi.org/10.18632/oncotarget.17966
|
| 44440-44446 |
|
| Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG |
|
https://doi.org/10.18632/oncotarget.17968
|
| 44447-44464 |
|
| M2 tumorassociated macrophages produce interleukin17 to suppress oxaliplatininduced apoptosis in hepatocellular carcinoma |
|
https://doi.org/10.18632/oncotarget.17973
|
| 44465-44476 |
|
| Associations between APOE genotype and cerebral smallvessel disease: a longitudinal study |
|
https://doi.org/10.18632/oncotarget.17724
|
| 44477-44489 |
|
| Interleukin6174G>C gene promoter polymorphism and prognosis in patients with cancer |
|
https://doi.org/10.18632/oncotarget.17771
|
| 44490-44497 |
|
| Cell typedependent HIF1 αmediated effects of hypoxia on proliferation migration and metastatic potential of human tumor cells |
|
https://doi.org/10.18632/oncotarget.17806
|
| 44498-44510 |
|
| Methionine restriction on oxidative stress and immune response in dssinduced colitis mice |
|
https://doi.org/10.18632/oncotarget.17812
|
| 44511-44520 |
|
| Actual over 10year survival after liver resection for patients with intrahepatic cholangiocarcinoma |
|
https://doi.org/10.18632/oncotarget.17815
|
| 44521-44532 |
|
| U94 of human herpesvirus 6 downmodulates Src promotes a partial mesenchymaltoepithelial transition and inhibits tumor cell growth invasion and metastasis |
|
https://doi.org/10.18632/oncotarget.17817
|
| 44533-44549 |
|
| Rapalogs can promote cancer cell stemness in vitro in a Galectin1 and Hrasdependent manner |
|
https://doi.org/10.18632/oncotarget.17819
|
| 44550-44566 |
|
| The bidirectional association between oral cancer and esophageal cancer: A populationbased study in Taiwan over a 28year period |
|
https://doi.org/10.18632/oncotarget.17818
|
| 44567-44578 |
|
| Intravoxel incoherent motion diffusionweighted MR imaging parameters predict pathological classification in thymic epithelial tumors |
|
https://doi.org/10.18632/oncotarget.17857
|
| 44579-44592 |
|
| The effect of thermal dose on hyperthermiamediated inhibition of DNA repair through homologous recombination |
|
https://doi.org/10.18632/oncotarget.17861
|
| 44593-44604 |
|
| The collagen receptor uPARAP/Endo180 as a novel target for antibodydrug conjugate mediated treatment of mesenchymal and leukemic cancers |
|
https://doi.org/10.18632/oncotarget.17883
|
| 44605-44624 |
|
| Dimethyl fumarate reduces the risk of mycotoxins via improving intestinal barrier and microbiota |
|
https://doi.org/10.18632/oncotarget.17886
|
| 44625-44638 |
|
| Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1specific inhibitor on breast cancer cells |
|
https://doi.org/10.18632/oncotarget.17961
|
| 44639-44653 |
|
| Stable and high expression of Galectin8 tightly controls metastatic progression of prostate cancer |
|
https://doi.org/10.18632/oncotarget.17963
|
| 44654-44668 |
|
| BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity |
|
https://doi.org/10.18632/oncotarget.17965
|
| 44669-44681 |
|
| Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK3βdependent increases in mitochondrial membrane permeability |
|
https://doi.org/10.18632/oncotarget.17967
|
| 44682-44693 |
|
| FOXP3 inhibits cancer stem cell selfrenewal via transcriptional repression of COX2 in colorectal cancer cells |
|
https://doi.org/10.18632/oncotarget.17974
|
| 44694-44704 |
|
| Genomewide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer |
|
https://doi.org/10.18632/oncotarget.18348
|
| 44705-44719 |
|
| Antagonistic effects of lycopene on cadmiuminduced hippocampal dysfunctions in autophagy calcium homeostatis and redox |
|
https://doi.org/10.18632/oncotarget.18249
|
| 44720-44731 |
|
| Catecholamines facilitate VEGFdependent angiogenesis via β2adrenoceptorinduced Epac1 and PKA activation |
|
https://doi.org/10.18632/oncotarget.17267
|
| 44732-44748 |
|
| Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patientderived murine xenografts |
|
https://doi.org/10.18632/oncotarget.17432
|
| 44749-44760 |
|
| Human 8oxoguanine DNA glycosylase gene polymorphism Ser326Cys and cancer risk: updated metaanalysis |
|
https://doi.org/10.18632/oncotarget.16226
|
| 44761-44775 |
|
| Legume intake and risk of prostate cancer: a metaanalysis of prospective cohort studies |
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https://doi.org/10.18632/oncotarget.16794
|
| 44776-44784 |
Clinical Research Papers
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| Altered brain structural networks in attention deficit/hyperactivity disorder children revealed by cortical thickness |
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https://doi.org/10.18632/oncotarget.14734
|
| 44785-44799 |
|
| Hormonal therapy followed by chemotherapy or the reverse sequence as firstline treatment of hormoneresponsive human epidermal growth factor receptor2 negative metastatic breast cancer patients: results of an observational study |
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https://doi.org/10.18632/oncotarget.14735
|
| 44800-44810 |
|
| Safety and efficacy of canaloplasty versus trabeculectomy in treatment of glaucoma |
|
https://doi.org/10.18632/oncotarget.14757
|
| 44811-44818 |
|
| After microvascular decompression to treat trigeminal neuralgia both immediate pain relief and recurrence rates are higher in patients with arterial compression than with venous compression |
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https://doi.org/10.18632/oncotarget.14765
|
| 44819-44823 |
|
| Predictive value of hematological markers of systemic inflammation for managing cervical cancer |
|
https://doi.org/10.18632/oncotarget.14827
|
| 44824-44832 |
|
| Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers |
|
https://doi.org/10.18632/oncotarget.14908
|
| 44833-44841 |
|
| Phase III randomized trial of preoperative concurrent chemoradiotherapy versus preoperative radiotherapy for patients with locally advanced head and neck squamous cell carcinoma |
|
https://doi.org/10.18632/oncotarget.15107
|
| 44842-44850 |
|
| Young breast cancer patients who develop distant metastasis after surgery have better survival outcomes compared with elderly counterparts |
|
https://doi.org/10.18632/oncotarget.15268
|
| 44851-44859 |
|
| Endoscopic therapy for patients with pancreaticobiliary maljunction: a followup study |
|
https://doi.org/10.18632/oncotarget.16228
|
| 44860-44869 |
|
| The lymph node ratio as an independent prognostic factor for nodepositive triplenegative breast cancer |
|
https://doi.org/10.18632/oncotarget.17413
|
| 44870-44880 |
Reviews
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| Diabetes mellitus and the risk of gastric cancer: a metaanalysis of cohort studies |
|
https://doi.org/10.18632/oncotarget.16487
|
| 44881-44892 |
|
| The clinical role of microRNA21 as a promising biomarker in the diagnosis and prognosis of colorectal cancer: a systematic review and metaanalysis |
|
https://doi.org/10.18632/oncotarget.16488
|
| 44893-44909 |
|
| Association between HIF1A rs11549465 polymorphism and risk of prostate cancer: a metaanalysis |
|
https://doi.org/10.18632/oncotarget.16489
|
| 44910-44916 |
|
| The dark side of SOX2: cancer a comprehensive overview |
|
https://doi.org/10.18632/oncotarget.16570
|
| 44917-44943 |
|
| Dose dependent effects of cadmium on tumor angiogenesis |
|
https://doi.org/10.18632/oncotarget.16572
|
| 44944-44959 |
|
| Mechanisms of PD1/PDL1 expression and prognostic relevance in nonHodgkin lymphoma: a summary of immunohistochemical studies |
|
https://doi.org/10.18632/oncotarget.16680
|
| 44960-44975 |
|
| Thalidomide combined with transcatheter artierial chemoembolzation for primary hepatocellular carcinoma: a systematic review and metaanalysis |
|
https://doi.org/10.18632/oncotarget.16689
|
| 44976-44993 |
|
| Metaanalysis of the association between variants in MAPT and neurodegenerative diseases |
|
https://doi.org/10.18632/oncotarget.16690
|
| 44994-45007 |
|
| Physical activity and telomere length: Impact of aging and potential mechanisms of action |
|
https://doi.org/10.18632/oncotarget.16726
|
| 45008-45019 |
|
| Association between MMP21306 C/T polymorphism and prostate cancer susceptibility: a metaanalysis based on 3906 subjects |
|
https://doi.org/10.18632/oncotarget.16972
|
| 45020-45029 |
Corrections
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| Correction: Physiological characterization of a novel PPAR pan agonist 2456methylenedioxybenzo[d]thiazol2yl2methylphenoxy2methylpropanoic acid MHY2013 |
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https://doi.org/10.18632/oncotarget.18922
|
| 45030-45030 |
|
| Correction: Highlevel expression of P21Cdc/Racactivated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma |
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https://doi.org/10.18632/oncotarget.18923
|
| 45031-45031 |
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Oncotarget ® is a registered trademark of Rapamycin Press LLC
Impact Journals ® is a registered trademark of Rapamycin Press LLC
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